The difference

The origin of perfume is commonly attributed to the ancient Egyptians, Mesopotamians and ancient China.  Perfume oils had been popular through out ancient cultures dating as far back as 7000 BC. As time went on, creating perfume oil became unsustainable due to its tedious process and ingredients required. 

Modern day designer perfumes  have a lot of ingredients that the average consumer does not know about.

Petrochemicals, a chemical compound that are known to cause cancer, while it also gives you skin rashes, hormonal disorders and headaches.  

Alcohol, this is the bulk of any designer fragrance, 80% - 90% are often diluted. This is the number one reason why designer alcohol based perfumes don't last very long in comparison to oil perfumes.

Animal essences, intestine can be traced back to many designer fragrances.  The like of secretions, intestines, whale sperm are often used as the primary ingredients.